Despite similar rates of alanine release, fasting and diabetes affect de novo alanine synthesis differently
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چکیده
منابع مشابه
Alanine and Glutamine Synthesis and Release from Skeletal Muscle
The synthesis and release of alanine and glutamine were investigated with an intact rat epitrochlaris muscle preparation. This preparation will maintain on incubation for up to 6 hours, tissue levels of phosphocreatine, ATP, ADP, lactate, and pyruvate closely approximating those values observed in gastrocnemius muscles freeze-clamped in uiuo. The epitrochlaris preparation releases amino acids i...
متن کاملAlanine Aminotransferase, γ-Glutamyltransferase, and Incident Diabetes
OBJECTIVE To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes. RESEARCH DESIGN AND METHODS ALT and GGT were studied as determinants of diabetes in the British Women's Heart and Health Study, a cohort of 4,286 women 60-79 years old (median follow-up 7.3 years). A systematic review and a meta-analysis of 21 prospectiv...
متن کاملMuscle alanine synthesis and hepatic gluconeogenesis.
Gluconeogenesis is the metabolic process involving the synthesis de novo of glucose molecules from other carbon precursors during situations in which there is an enhanced oxidative utilization of body glucose or in which there is a dietary insufficiency of carbohydrate to supply the body requirements for oxidative glucose metabolism. Glucose synthesis is, for the most part, confined to the live...
متن کاملBiocatalytic Synthesis of Amino - Alcohols Using a de novo Designed Transketolase - P - Alanine : Pyruvate Transaminase Pathway in Escherichia coli
Biocatalysis continues to emerge as a powerful technique for the efficient synthesis of optically pure pharmaceuticals that are difficult to access via conventional chemistry. The power of a biocatalytic stage can be enhanced if two or more reactions can be achieved by a single whole cell biocatalyst containing a pathway designed de novo to facilitate a required synthetic sequence. This will al...
متن کاملStereospecific synthesis of a twinned alanine ester.
Reaction between 1,2-bis(2-hydroxyphenyl)-ethylenediamine (hpen) and methyl pyruvate gives the diaza-Cope rearrangement product with good yield and excellent stereospecificity. The product containing two chiral quaternary carbon centers is characterized by high performance liquid chromatography and X-ray crystallography. DFT computation provides insight into why the diaza-Cope rearrangement tak...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1998
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250050955